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Teriparatide acetate
CAS No. 99294-94-7
Teriparatide acetate ( Parathar acetate | hPTH 1-34 (acetate salt) | Forteo )
产品货号. M25029 CAS No. 99294-94-7
Teriparatide (Human parathymone Hormone-(1-34)) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide 是甲状旁腺激素的重组形式。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1134 | 有现货 |
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| 10MG | ￥1588 | 有现货 |
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| 25MG | ￥2390 | 有现货 |
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| 50MG | ￥3345 | 有现货 |
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| 100MG | ￥4172 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Teriparatide acetate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Teriparatide (Human parathymone Hormone-(1-34)) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide 是甲状旁腺激素的重组形式。
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产品描述Teriparatide (Human parathyroid hormone-(1-34)) is a PHT agonist, with an IC50 of 2 nM in HEK293 cells.Teriparatide is a recombinant form of parathyroid hormone.?It is an effective anabolic (i.e., bone growing) agent used to treat some forms of osteoporosis.?Intermittent use of Teriparatide activates osteoblasts more than osteoclasts, which leads to an overall increase in bone.(In Vivo):Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) (20 μg/kg, i.h.; daily, for 4 weeks; female New Zealand white rabbits) increases the cortical thickness and porosity.
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体外实验——
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体内实验Teriparatide acetate hydrate (Human parathyroid hormone-(1-34) acetate hydrate) (20 μg/kg, i.h.; daily, for 4 weeks; female New Zealand white rabbits) increases the cortical thickness and porosity. Animal Model:Female New Zealand white rabbits Dosage:20 μg/kg Administration:Subcutaneous injection; daily, for 4 weeksResult:Increased the pore ratio, number, and density as well as the cortical area, thickness, and bone mineral content (BMC), without significant influencing the volumetric bone mineral density (BMD).
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同义词Parathar acetate | hPTH 1-34 (acetate salt) | Forteo
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通路Others
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靶点Other Targets
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受体PHT
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研究领域——
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适应症——
化学信息
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CAS Number99294-94-7
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分子量4177.83
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分子式C183H295N55O53S2
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纯度>98% (HPLC)
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溶解度DMSO:Soluble; Water:Insoluble
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SMILESCC[C@H](C)[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC5=CNC=N5)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N.CC(=O)O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lindsay R, Krege JH, Marin F, Jin L, Stepan JJ. Teriparatide for osteoporosis: importance of the full course. Osteoporos Int. 2016 Feb 22. [Epub ahead of print] Review. PubMed PMID: 26902094.
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